NEJM：一篇有關鈣片與骨折預防文章的討論（台灣學者有加入討論）

2014/01/23

Calcium Supplements and Fracture Prevention — NEJM

我會想貼出來，是因為這是一篇不錯的小討論。而討論，必須提出科學證據，不是只會針對個人身份來批判。

三位台灣學者提出（提供3份佐證文獻）：

We concur with Bauer that dietary calcium is the best source of calcium. However, we do have some reservations regarding the use of calcium carbonate as a supplement....We propose that calcium citrate could be a better choice as a calcium supplement. （原文轉貼）

原來文章作者Douglas C. Bauer則回覆（提供5份佐證文獻））：

Huang et al. propose that supplementation with calcium citrate is preferred over supplementation with calcium carbonate because of the frequent concurrent use of proton-pump inhibitors for dyspepsia.

Although observational studies have suggested that prolonged use of proton-pump inhibitors is associated with an increased risk of fracture, the mechanism remains uncertain and the benefits of calcium supplementation of any type in patients who receive proton-pump inhibitors are not known. （原文轉貼）

雙方都以科學報告為佐證，提出合理、嚴謹的看法。這是非常棒的討論。

另外一個有趣的，是台灣居然是三位學者一起投「To the editor：」，罕見。